As merchants switch their sales to e-commerce, online marketplaces for handmade goods, like Etsy and ArtFire, make it extremely easy for artisans who can produce a steady supply of quality handmade products, such as crocheted blankets or unique painted glassware. If you have a unique craft, this is a good way to earn income while you're at home, doing what you love.
In the long-term, it affects your versatility, functionality, and, of course, your brand. In the short term, it can certainly add/take away a lot of headaches. That said, just like choosing a physical house or office, there is no such thing as an absolute “best” or “top” choice. There’s only the right choice relative to your goals, experience, and circumstances.