There's an audience for everything, even if it's as specific as dollhouse furniture or organic dog food. With a niche e-commerce store, you can reach customers who seek your specific products. Building a business in a niche market can help you differentiate yourself from other brands and build your credibility and expertise. Look to social media or your own consumer needs to come up with a product to sell online.  
When one of your customers makes a purchase, you purchase the product from a third-party company (the drop shipper, usually a manufacturer or wholesaler) for a lower price. This process is as simple as forwarding the order from your customer, a process that can actually be completely automated. (Remember you don't have any risk here of buying inventory because the sale has already been made).
In the long-term, it affects your versatility, functionality, and, of course, your brand. In the short term, it can certainly add/take away a lot of headaches. That said, just like choosing a physical house or office, there is no such thing as an absolute “best” or “top” choice. There’s only the right choice relative to your goals, experience, and circumstances.
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